Daniel Hurtado. Pontificia Universidad Católica de Chile
Primal and mixed finite-element schemes for image registration and biomechanical analysis of the lung
Auditorio San Agustín, Escuela de Ingeniería, Campus San Joaquín, UC
Respiratory diseases are the third leading cause of death in the world. In chronic respiratory diseases, most of the symptoms can be explained by drastic changes in the mechanical properties and deformation mechanisms occurring in the lung tissue and airways at a regional, rather than whole-organ, level. The need for a regional mechanical analysis has motivated the development of computational tools for the assessment of regional lung mechanics from medical images, which hold promise in the creation of more effective diagnostic tools in respiratory medicine.
In this talk, I will introduce the problem of image registration and biomechanical analysis in the context of regional lung mechanics. Then, I will present a mixed formulation of the image registration problem that allows for a seamless analysis of the stresses and strain in the lung tissue. Finite-element schemes will be presented to solve both the primal and mixed formulations of the image registration problem, along with their corresponding numerical analysis. I will end the presentation with some applications of the image-based biomechanical tools we have developed in the study of ventilator-induced lung injury.
This work is a joint collaboration with Nicolás Barnafi (former UC student, now at Politecnico di Milano) and Gabriel Gatica (Universidad de Concepción).