Ingrid Guevara Romero. Pontificia Universidad Católica de Chile
Bayesian Multiple Comparisons with Applications to Alzheimer's data
Sala 3, Facultad de Matemáticas
Abstract:
Multiple-comparison methods are widely used in medicine, engineering, and the social sciences to determine whether groups differ. Applications range from comparing medical treatments and biological populations to evaluating environmental or technological interventions. Classical approaches, such as Tukey or Dunnett tests, remain standard tools for these problems, but they often rely on restrictive assumptions, including Gaussianity, equal variances, or specific data types. In practice, however, real-world data are frequently heterogeneous, asymmetric, multimodal, or measured on nonstandard scales, limiting the applicability of traditional methods.
This project develops a new Bayesian framework for multiple comparisons that is broadly applicable across scientific disciplines. The proposed methodology formulates the problem as one of identifying which groups share the same underlying data-generating mechanism and which differ. Within this framework, competing hypotheses are represented as probabilistic models, allowing uncertainty to be naturally incorporated into the analysis while simultaneously controlling false discoveries through a novel prior distribution that penalizes overly complex group structures, encouraging parsimonious and interpretable solutions while preserving sensitivity to meaningful differences.
Unlike many existing approaches, the method requires only independence across samples and can adapt automatically to complex distributional features.
The methodology is motivated by applications in areas where reliable group comparisons are essential, including biomedical research and disease detection. In particular, the framework is illustrated through an application to Alzheimer's disease, where detecting subtle population differences may improve diagnostic strategies.